Q&A: All you need to know about DOXYPEP in 2024

DoxyPEP, or doxycycline post-exposure prophylaxis, is a preventive treatment aimed at reducing the risk of contracting bacterial sexually transmitted infections (STIs) such as syphilis, chlamydia, and gonorrhoea.

Clinical trials have shown that DoxyPEP can significantly lower the incidence of these STIs among men who have sex with men (MSM) and transgender women (TGW), making it a promising tool in the ongoing effort to curb the spread of these infections. While DoxyPEP is highly effective when taken promptly, it is not a substitute for other preventive measures. It should be used in conjunction with regular STD testing and safe sex practices.

What is DoxyPEP, and how does it work?

DoxyPEP stands for doxycycline post-exposure prophylaxis. It is a preventive treatment involving a single dose of the antibiotic doxycycline taken after a potential exposure to bacterial STIs. It works by preventing the bacteria that cause syphilis, chlamydia, and gonorrhea from establishing an infection in the body.

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Who should consider taking DoxyPEP?

DoxyPEP is recommended for individuals assigned male at birth who have had a bacterial STI (syphilis, chlamydia, gonorrhoea) in the past year or have engaged in condomless oral or anal sex with a male partner in the past year. If you meet these criteria or believe you might benefit from DoxyPEP, discuss it with your healthcare provider.

How effective is DoxyPEP in preventing STIs?

Studies have shown that DoxyPEP can significantly reduce the risk of contracting syphilis and gonorrhoea by 90% and chlamydia by about 50–55%. It is most effective when taken within 24 hours after a potential exposure, but it can still be beneficial if taken within 72 hours.

Are there any side effects or risks associated with taking DoxyPEP?

Common side effects of doxycycline include nausea, vomiting, diarrhoea, and increased sensitivity to sunlight. Taking it with food and water can help minimize these side effects. There is also a concern about the potential for developing antibiotic resistance, so it's essential to use DoxyPEP as directed and under the supervision of a healthcare provider.

Can I take DoxyPEP alongside other medications or preventive measures?

Yes, DoxyPEP can be safely taken alongside HIV PrEP and other medications. However, you should avoid taking it within two hours of multivitamins, fiber, or supplements, as these can interfere with absorption. Always inform your healthcare provider about all medications and supplements you are taking.

What are the side effects of DoxyPEP?

The side effects of DoxyPEP (doxycycline post-exposure prophylaxis) can include gastrointestinal issues such as nausea, vomiting, and diarrhoea, as well as increased sensitivity to sunlight (photosensitivity), which raises the risk of sunburn. Other potential side effects are oesophagal irritation, which can be minimized by taking the medication with plenty of water and not lying down immediately after, and rare allergic reactions like a rash or difficulty breathing. Additionally, some individuals might experience skin reactions or yeast infections. These side effects are typically mild and manageable, but discussing any concerns with a healthcare provider is important.

How do I obtain DoxyPEP, and what is the dosing regimen?

To obtain DoxyPEP, schedule an appointment with your healthcare provider to discuss your eligibility. If eligible, you will undergo STI testing and basic bloodwork. Once confirmed, you will receive a prescription for doxycycline. The dosing regimen is two 100mg tablets (200mg total) taken within 72 hours of a condomless sexual encounter, ideally within the first 24 hours.

Do I need to follow up with my healthcare provider while taking DoxyPEP?

Yes, it's essential to follow up with your healthcare provider every three months for routine STI testing, standard bloodwork, and prescription refills. If you experience symptoms of an STI or have a known exposure while taking DoxyPEP, seek immediate testing and treatment.

All In All

DoxyPEP's implementation addresses the rising incidence of bacterial STIs, providing additional protection for individuals at higher risk. However, its use requires careful consideration of potential side effects, such as nausea, increased sensitivity to sunlight, and the broader public health concern of antibiotic resistance.

Patients considering DoxyPEP should consult their healthcare providers to determine eligibility and ensure appropriate monitoring. Regular follow-up appointments for STI testing and health assessments are crucial to maintaining effectiveness and safety.

If you're considering DOXYPEP after high-risk sexual exposure, contact us at info.bkk@pulse-clinic.com or any of the following platforms for more information.

+66 65 237 1936   @PULSEClinic   PulseClinic