&lt;p&gt;&lt;span style=&quot;color: #999999;&quot;&gt;Written by Icetim, Translated by Icetim and &lt;a href=&quot;../../en/pulseteam/6&quot;&gt;Dannie&lt;/a&gt;, Medically Approved by &lt;a href=&quot;../../pulseteam/1&quot;&gt;Dr. Wichakorn&lt;/a&gt; on 30 JUNE 2020&lt;br /&gt;&lt;br /&gt;&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #cc99ff;&quot;&gt;Trade Name:&amp;nbsp;&lt;span style=&quot;font-size: 14px; text-align: justify; color: #999999;&quot;&gt;&lt;br /&gt;&lt;/span&gt;&lt;/span&gt;ISENTRESS&amp;reg;&lt;span style=&quot;color: #cc99ff;&quot;&gt;&lt;br /&gt;&lt;br /&gt;Generic Name:&amp;nbsp;&lt;/span&gt;&lt;span style=&quot;font-size: 14px; text-align: justify; color: #999999;&quot;&gt;&lt;br /&gt;&lt;/span&gt;Raltegravir 400 mg&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #cc99ff;&quot;&gt;Mechanism of Action:&amp;nbsp;&lt;br /&gt;&lt;/span&gt;The drug inhibits the activity of HIV-1 integrase, which impedes the insertion of HIV-1 DNA into the host cell genome. Integrase is a vital enzyme that catalyzes two, which must occur for viral DNA insertion into the host DNA. Primarily, it removes two deoxynucleotides from the 3 ends of the viral DNA. When the reaction is complete, the enzyme is also responsible for covalently binding viral DNA to that of the host cell.&lt;br /&gt;For more information, please&amp;nbsp;&lt;a href=&quot;http://www.antimicrobe.org/d98.asp&quot;&gt;Click&lt;/a&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #cc99ff;&quot;&gt;Indication:&amp;nbsp;&lt;br /&gt;&lt;/span&gt;Raltegravir indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection in adult patients. To improve the chance of fighting HIV-1 infection, raltegravir must be taken with other HIV medicines.&lt;br /&gt;Indications and Usage, please&amp;nbsp;&lt;a href=&quot;https://aidsinfo.nih.gov/drugs/420/raltegravir/13/professional&quot;&gt;Click&lt;/a&gt;&lt;br /&gt;&lt;br /&gt;&lt;span style=&quot;color: #cc99ff;&quot;&gt;Other Indication:&amp;nbsp;&lt;br /&gt;&lt;/span&gt;Post-Exposure Prophylaxis (PEP)&lt;/p&gt;
&lt;p style=&quot;-qt-block-indent: 0; text-indent: 0px; margin: 0px;&quot;&gt;&lt;span style=&quot;color: #cc99ff;&quot;&gt;Side effect:&lt;br /&gt;&lt;/span&gt;&lt;strong&gt;&amp;bull;&lt;/strong&gt; The most common side effects were insomnia, headache, nausea, dizziness, and fatigue.&lt;br /&gt;&lt;strong&gt;&amp;bull;&lt;/strong&gt; The most commonly reported side effects included diarrhea, nausea, headache, nasopharyngitis, fatigue, abdominal pain, and vomiting&lt;br /&gt;For more information, please&amp;nbsp;&lt;a href=&quot;https://www.drugs.com/sfx/isentress-side-effects.html&quot;&gt;Click&lt;/a&gt;&lt;/p&gt;
&lt;p style=&quot;-qt-block-indent: 0; text-indent: 0px; margin: 0px;&quot;&gt;&amp;nbsp;&lt;/p&gt;
&lt;p style=&quot;-qt-block-indent: 0; text-indent: 0px; margin: 0px;&quot;&gt;&lt;span style=&quot;color: #cc99ff;&quot;&gt;Drug Interaction:&lt;br /&gt;&lt;/span&gt;There are 11 major&amp;nbsp;drug interactions&lt;br /&gt;&lt;strong&gt;&amp;bull;&lt;/strong&gt; aluminum carbonate&lt;br /&gt;&lt;strong&gt;&amp;bull;&amp;nbsp;&lt;/strong&gt;aluminum hydroxide&lt;br /&gt;&lt;strong&gt;&amp;bull;&lt;/strong&gt;&amp;nbsp;calcium carbonate&lt;br /&gt;&lt;strong&gt;&amp;bull;&lt;/strong&gt; dihydroxyaluminum sodium carbonate&lt;br /&gt;&lt;strong&gt;&amp;bull;&lt;/strong&gt; magaldrate&lt;br /&gt;&lt;strong&gt;&amp;bull;&lt;/strong&gt; magnesium carbonate&lt;br /&gt;&lt;strong&gt;&amp;bull;&lt;/strong&gt; magnesium hydroxide&lt;br /&gt;&lt;strong&gt;&amp;bull;&lt;/strong&gt; rifampin&lt;br /&gt;&lt;strong&gt;&amp;bull;&lt;/strong&gt;&amp;nbsp;zinc acetate&lt;br /&gt;&lt;strong&gt;&amp;bull;&amp;nbsp;&lt;/strong&gt;zinc gluconate&lt;br /&gt;&lt;strong&gt;&amp;bull;&amp;nbsp;&lt;/strong&gt;zinc sulfate&lt;br /&gt;There are&amp;nbsp;4 disease interactions&amp;nbsp;with raltegravir which include:&lt;br /&gt;&lt;strong&gt;&amp;bull;&amp;nbsp;&lt;/strong&gt;hemodialysis&lt;br /&gt;&lt;strong&gt;&amp;bull;&amp;nbsp;&lt;/strong&gt;liver disease&lt;br /&gt;&lt;strong&gt;&amp;bull;&amp;nbsp;&lt;/strong&gt;myopathy/rhabdomyolysis&lt;br /&gt;&lt;strong&gt;&amp;bull;&amp;nbsp;&lt;/strong&gt;PKU&lt;/p&gt;
&lt;p style=&quot;-qt-block-indent: 0; text-indent: 0px; margin: 0px;&quot;&gt;For more drug interactions with Raltegravir, please&amp;nbsp;&lt;a href=&quot;https://www.drugs.com/drug-interactions/raltegravir-index.html&quot;&gt;Click&lt;/a&gt;&lt;br /&gt;&lt;br /&gt;&lt;/p&gt;
&lt;p style=&quot;-qt-block-indent: 0; text-indent: 0px; margin: 0px;&quot;&gt;&lt;span style=&quot;color: #cc99ff;&quot;&gt;Pregnancy:&lt;br /&gt;&lt;/span&gt;&lt;strong&gt;&amp;bull;&amp;nbsp;&lt;/strong&gt;Raltegravir should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus. Raltegravir is classified as FDA pregnancy risk category C.&amp;nbsp;&lt;/p&gt;
&lt;p style=&quot;-qt-block-indent: 0; text-indent: 0px; margin: 0px;&quot;&gt;&lt;strong&gt;&amp;bull;&amp;nbsp;&lt;/strong&gt;Breastfeeding is not recommended during use of this drug.&lt;/p&gt;
&lt;p style=&quot;-qt-block-indent: 0; text-indent: 0px; margin: 0px;&quot;&gt;&amp;nbsp;&lt;/p&gt;
&lt;p style=&quot;-qt-block-indent: 0; text-indent: 0px; margin: 0px;&quot;&gt;&lt;span style=&quot;color: #cc99ff;&quot;&gt;Alcohol, Drug and Supplement:&lt;br /&gt;&lt;/span&gt;No alcohol and supplements interactions were found.&lt;/p&gt;
&lt;p style=&quot;-qt-block-indent: 0; text-indent: 0px; margin: 0px;&quot;&gt;&amp;nbsp;&lt;/p&gt;
&lt;p style=&quot;-qt-block-indent: 0; text-indent: 0px; margin: 0px;&quot;&gt;&lt;span style=&quot;color: #cc99ff;&quot;&gt;Availability:&lt;br /&gt;&lt;/span&gt;Prescription only. Contact PULSE CLINIC.&lt;/p&gt;
&lt;p style=&quot;-qt-block-indent: 0; text-indent: 0px; margin: 0px;&quot;&gt;&amp;nbsp;&lt;/p&gt;
&lt;p style=&quot;-qt-block-indent: 0; text-indent: 0px; margin: 0px;&quot;&gt;References:&lt;br /&gt;&lt;span style=&quot;color: #3366ff;&quot;&gt;&lt;a href=&quot;https://www.medicinenet.com/raltegravir/article.htm#what_is_raltegravir_and_how_does_it_work_mechanism_of_action&quot;&gt;https://www.medicinenet.com/raltegravir&lt;/a&gt;&amp;nbsp;&lt;br /&gt;&lt;a href=&quot;https://www.drugs.com/drug-interactions/raltegravir-index.html&quot;&gt;https://www.drugs.com/drug-interactions/raltegravir-index.html&lt;/a&gt;&lt;br /&gt;&lt;a href=&quot;https://www.drugs.com/sfx/isentress-side-effects.html&quot;&gt;https://www.drugs.com/sfx/isentress-side-effects.html&lt;/a&gt;&lt;br /&gt;&lt;a href=&quot;http://www.antimicrobe.org/d98.asp&quot;&gt;http://www.antimicrobe.org/d98.asp&lt;/a&gt;&amp;nbsp;&lt;/span&gt;&lt;/p&gt;

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